The two greats have joined forces with the boxing champion, 'knocking out' the rapper for his new music video 'Godzilla'.
In the video, Mike Tysonplants a right hook on the rapper without being seen. After a moment of blackness, 'the knockout' Eminem regains consciousness saying 'What the f**k?' and Tyson's face is revealed.
Tyson then apologizes to Eminem in the video: "Em, is that you? Ah, I didn't mean this. Please, man, I'm sorry. Please forgive me. F**k.".
The comedy is ripe, but anybody who has faced Tyson in the ring would not be laughing so hard.
The music video is also full of easter eggs and hidden references, even Dr Dre features as an actual doctor once again :
Eminem is also keeping some classic imagery going by being covered in blood and a nod to a past 'slim shady' features in some tape over Eminem's mouth. These may perhaps be some small easter eggs but a tried and true fan will be able to pick them, out.
There are even recreations of scenes in past music videos such as 'My Name Is' and 'Bonnie and Clyde'.
Watch the video below and see if you can spot all the references!